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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Flow cytometric analysis of Hela cells using APC mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to APC

  • 货号:

    30669
  • 别名:

    GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
  • 产品上架时间:

    2024-01-01
  • 应用:

    FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P25054
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to APC

Description

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

References

1. Gastroenterology. 2012 Jan;142(1):71-77.
2. Mol Cancer. 2011 Aug 22;10:101.

Specification

Aliases GS; DP2; DP3; BTPS2; DP2.5; PPP1R46
Entrez GeneID 324
Swissprot P25054
clone 1F7G2
WB Predicted band size 311.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human APC (AA: 2644-2843) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

FCM 1/200 - 1/400
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30669