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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, A549 cells, Primary antibody: P10631(APAF1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes

The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10631(APAF1 Antibody) at dilution 1/20. (Original magnification: ×200)

The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P10631(APAF1 Antibody) at dilution 1/20. (Original magnification: ×200)

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Rabbit Polyclonal Antibody to APAF1

货号：
P10631
别名：
CED4
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human, Mouse, Rat
抗体类型：
Primary antibody
Swissprot：
O14727
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to APAF1

Description
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Description

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Specification
Aliases	CED4
Swissprot	O14727
WB Predicted band size	142 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human APAF1
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.