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The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09617(DENND1B Antibody) at dilution 1/100. (Original magnification: ×200)

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Rabbit Polyclonal Antibody to DENND1B

货号：
P09617
别名：
FAM31B; C1ORF18; C1orf218
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human, Mouse
抗体类型：
Primary antibody
Swissprot：
Q6P3S1
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to DENND1B

Description
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

Description

Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).

Specification
Aliases	FAM31B; C1ORF18; C1orf218
Swissprot	Q6P3S1
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Fusion protein of human DENND1B
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.