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Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell, Primary antibody: P02229(NSMCE2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds

The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P02229(NSMCE2 Antibody) at dilution 1/40. (Original magnification: ×200)

The image is immunohistochemistry of paraffin-embedded Human brain tissue using P02229(NSMCE2 Antibody) at dilution 1/40. (Original magnification: ×200)

Rabbit Polyclonal Antibody to NSMCE2

货号：
P02229
别名：
NSE2; MMS21; ZMIZ7; C8orf36
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human, Mouse, Rat
抗体类型：
Primary antibody
Swissprot：
Q96MF7
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to NSMCE2

Description
NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Description

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Specification
Aliases	NSE2; MMS21; ZMIZ7; C8orf36
Swissprot	Q96MF7
WB Predicted band size	28 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Full length fusion protein
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.