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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: PC3 cells, hepg2 cells, human fetal liver tissue, Primary antibody: P12143(SDHB Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds

The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12143(SDHB Antibody) at dilution 1/30. (Original magnification: ×200)

The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12143(SDHB Antibody) at dilution 1/30. (Original magnification: ×200)

Rabbit Polyclonal Antibody to SDHB

货号：
P12143
别名：
IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human, Mouse, Rat
抗体类型：
Primary antibody
Swissprot：
P21912
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to SDHB

Description
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Description

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Specification
Aliases	IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
Swissprot	P21912
WB Predicted band size	32 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human SDHB
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.