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Mouse Monoclonal Antibody to MCP-1

  • 货号:

    20014
  • 别名:

    MCP1
  • 产品上架时间:

    2024-01-01
  • 应用:

  • 反应种属:

  • 抗体类型:

    Primary antibody
  • Swissprot:

    P13500
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to MCP-1

Description

Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

References

1. Yoshimura T. et al. 1989. FEBS Lett. 244:487-493.
2. Yoshimura T. et al. 1991. Adv. Exp. Med. Biol. 305:47-56.
3. Rollins B.J. et al. 1991. Genomics. 10:489-492.

Specification

Aliases MCP1
Entrez GeneID 6347
Swissprot P13500
clone 1A7B8
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Immunogen Purified recombinant fragment of human MCP-1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

ELISA 1/10000

Product Image

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#20014