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Mouse Monoclonal Antibody to Human P16
-
货号:
20137 -
别名:
Human P16 -
产品上架时间:
2024-01-01 -
应用:
IHC -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
P42771 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180
Mouse Monoclonal Antibody to Human P16
Description |
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p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. |
References |
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1. Bai, F. et al. Mol. Cell. Biol.2003 23, 1269-1277. 2. Lowe, S.W. and Sherr, C.J. Curr. Opin. Genet.2003 Dev.13, 77-83. 3. Sherr, C.J. Nat. Rev. Mol. Cell Biol.2001 2, 731-737. |
Specification |
|
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Aliases | Human P16 |
Entrez GeneID | 1029 |
Swissprot | P42771 |
clone | 5A8A4; 3G8D12 |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of P16 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
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IHC | 1/200 - 1/1000 |
ELISA | 1/10000 |
Product Image
- Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma (A), esophageal squamous cell carcinoma (B), hepatic cell carcinoma (C), thyroid tumor (D), breast adenofibroma (E), breast infiltrating ductal carcinoma (F), normal cerebrum tissue (G), normal colon tissue (H), normal esophageal tissue (I), showing nuclear localization using P16 mouse mAb with DAB staining.
- Immunohistochemical analysis of paraffin-embedded human spleen tissues using P16 mouse mAb.
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#20137
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