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Western blot analysis using GSK3 alpha mouse mAb against Hela (1) and PC-3 cell lysate.
Immunofluorescence analysis of Hela cells using GSK3 alpha mouse mAb showing cytoplasmic localization.

Mouse Monoclonal Antibody to GSK3 alpha

  • 货号:

    20133
  • 别名:

    DKFZp686D0638; GSK3A
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IF
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P49840
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to GSK3 alpha

Description

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

References

1. Mendez P, Garcia-Segura LM. Endocrinology. 2006 Jun;147(6):3027-39. Epub 2006 Feb 23.
2. Bianchi M, De Lucchini S, et, al. Biochem J. 2005 Oct 15;391(Pt 2):359-70.
3. De Servi B, Hermani A, Medunjanin S, Mayer D. Oncogene. 2005 Jul 21;24(31):4946-55.

Specification

Aliases DKFZp686D0638; GSK3A
Entrez GeneID 2931
Swissprot P49840
clone 9D5G1
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of GSK3 alpha expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

WB 1/500 - 1/2000
IF 1/200 - 1/1000
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#20133