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Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Rat brain tissue and Mouse brain tissue lysates, Primary antibody: P02940(NGEF Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds

The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P02940(NGEF Antibody) at dilution 1/35. (Original magnification: ×200)

The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P02940(NGEF Antibody) at dilution 1/35. (Original magnification: ×200)

Rabbit Polyclonal Antibody to NGEF

货号：
P02940
别名：
EPHEXIN; ARHGEF27
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human, Mouse, Rat
抗体类型：
Primary antibody
Swissprot：
Q8N5V2
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to NGEF

Description
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Description

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Specification
Aliases	EPHEXIN; ARHGEF27
Swissprot	Q8N5V2
WB Predicted band size	82 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human NGEF
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.