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Immunohistochemical analysis of paraffin-embedded Classical Hodgkin lymphoma. 1, Antibody was diluted at 1:200. 2, Tris-EDTA,pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200.

Mouse Monoclonal Antibody to BOB.1

货号：
50028
别名：
POU2AF1, OBF1
产品上架时间：
2024-01-01
应用：
IHC,ELISA
反应种属：
Human,Mouse,
抗体类型：
Primary antibody
Swissprot：
Q16633
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to BOB.1

Description
disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,

Description

disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.,function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the POU2AF1 family.,tissue specificity:B-cell specific.,

Specification
Aliases	POU2AF1, OBF1
Entrez GeneID	5450
Swissprot	Q16633
clone	8H2D7
WB Predicted band size	27kDa
Host/Isotype	Mouse IgG2a,Kappa
Antibody Type	Primary antibody
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Species Reactivity	Human,Mouse,
Immunogen	Synthesized peptide derived from human BOB.1 AA range: 150-256
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA