Rabbit Polyclonal Antibody to MLTK

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.Gotoh I., J. Biol. Chem. 276:4276-4286(2001). Bloem L.J., J. Mol. Cell. Cardiol. 33:1739-1750(2001).Gross E.A., J. Biol. Chem. 277:13873-13882(2002).