Mouse Monoclonal Antibody to MSH2

Description
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

References
1.Anticancer Res. 2018 May;38(5):2841-2848. 2.Biochem Biophys Res Commun. 2015 Jan 2;456(1):506-12.

Specification
Aliases	FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1
Entrez GeneID	4436
Swissprot	P43246
clone	4F10D6
WB Predicted band size	104.7kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human MSH2 (AA: 442-586) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
FCM	1/200 - 1/400
ELISA	1/10000