Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

References
Asian Pac J Cancer Prev. 2013;14(1):315-20. Blood. 2012 Jul 12;120(2):347-55.

Specification
Aliases	TAK1; MEKK7; TGF1a
Entrez GeneID	6885
Swissprot	O43318
clone	3E8H4
WB Predicted band size	67.2kDa
Host/Isotype	Mouse IgG2a
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

Application
ELISA	1/10000