Description

This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants.

References
1.PLoS Genet. 2014 Nov 20;10(11):e1004788. 2.PLoS One. 2014 Jun 10;9(6):e99294.

Specification
Aliases	LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
Entrez GeneID	2903
Swissprot	Q12879
clone	3G10F9
WB Predicted band size	165.3kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human GRIN2A (AA: extra 23-165) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
FCM	1/200 - 1/400
ELISA	1/10000