Description

CD8 T cell surface antigen is heterodimer of an alpha and a beta chain linked by two disulfide bonds .It belongs type I membrane protein. Selectively expressing of CD8 on a subset of T cells leads to CD8 T cell development. Through identifying cytotoxic/suppressor T-cells that interact with MHC class I bearing targets, CD8 is thought to play a role in the process of T-cell mediated killing. Veillette et al (1988) found the CD8 is associated with the internal membrane tyrosine-protein kinase p56lck.

References
1. Veillette, A. et al. 1988. Cell 55:301.

Specification
Aliases	MAL; p32; Leu2; CD8A
Entrez GeneID	925
Swissprot	P01732
clone	RAVB3
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CD8 expressed in E. Coli.
Formulation	Purified antibody in PBS containing 0.03% sodium azide.

Application
FCM	1/200 - 1/400
ELISA	1/10000