Description

MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.

References
1. Mol Cell Biol. 1993 Aug;13(8):4679-90. 2. Eur J Biochem. 1995 Nov 15;234(1):32-8. 3. Oncogene. 1998 Jul 9;17(1):57-65.

Specification
Aliases	MEK2; MKK2; MAPKK2
Entrez GeneID	5605
Swissprot	P36507
clone	7F5
WB Predicted band size	44kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Purified recombinant fragment of human MAP2K2 expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
WB	1/500 - 1/2000
ICC	1/200 - 1/1000
FCM	1/200 - 1/400
ELISA	1/10000