Description

PR(progesterone receptor), with 933-amino acid protein (about 110kDa), a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone, PR is mediated by two functionally different isoforms of the progesterone receptor, the full length PR-B and the short form PR-A. The PR-A and PR-B proteins are 94 kDa and 114 kDa respectively. That are equimolar in the normal breast but dysregulated in advanced disease. PR is prognostic markers in breast cancers irrespective of the patient's progestational status Human progesterone.

References
1. McGuire, W.L., et al. 1986. Cancer.Surv.5:527-536. 2. Helena CD, Curt WB, Paul V,et al. 2000. J.Clin. Pathol. 53:201-205. 3. Wen, D.X., et al. 1994.Mol.Cell.Biol.14:8356-8364. 4. GM Clark, CK Osborne, WL McGuire.1984.J. Clin. Oncol., 2:1102-1109.

Specification
Aliases	PR; NR3C3; PGR
Entrez GeneID	5241
Swissprot	P06401
clone	2F12B4
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of PR expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
IHC	1/200 - 1/1000
ELISA	1/10000