Description

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

References
1. J Immunol. 2012 Oct 15;189(8):3822-30. 2. Cancer. 2012 Dec 15;118(24):6110-7.

Specification
Aliases	FLK2; STK1; CD135; FLK-2
Entrez GeneID	2322
Swissprot	P36888
clone	7B7C3
WB Predicted band size	130kDa
Host/Isotype	Mouse IgG1
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
IHC	1/200 - 1/1000
ELISA	1/10000